Overview of the 2018 PsychENCODE Rollout

Introductory papers

• Revealing the brain's molecular architecture
• Human brain samples yield a genomic trove

Papers

• Adult Capstone - Comprehensive functional genomic resource and integrative model for the human brain
  • One page summary: Proofs, Text, Figure
  • Fun pics of cell-type specfic regulatory networks, based on single-cell data (Big JPEG Wheel) (PDF blow-ups)
  • Lectures on the Adult Capstone: i0sigma, i0mssm18
  • Resource.psychencode.org
• Developmental Capstone - Integrative Functional Genomic Analysis of Human Brain Development and Neuropsychiatric Risk
  • Development.psychencode.org & BrainSpan.org
• Disorder Capstone - Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
• Transcriptome and epigenome landscape of human cortical development modeled in brain organoids
  • One page summary

Press

• NY Times - Mapping the Brain’s Genetic Landscape
• Science News - PsychENCODE hints at the genetic origins of mental disorders
• Nature News - Huge brain study uncovers ‘buried’ genetic networks linked to mental illness
• Yale News - In the developing brain, scientists find roots of neuropsychiatric diseases
• GenomeWeb - PsychENCODE Studies Explore Brain Development, Neuropsychiatric Regulatory Features
• UPI.com - Genetic analysis reveals brain changes that lead to mental illness
• Scientific American - Huge Brain Study Uncovers “Buried” Genetic Networks Linked to Mental Illness
• The Scientist Magazine(R) - Analysis of 2,000 Brains Provides Clues to Schizophrenia, Autism
• Axios - Mapping the brain to see how diseases may start
• STAT - With data from 2,000 brains, studies explore psychiatric diseases
• Medicalxpress.com - Researchers uncover molecular mechanisms linked to autism and schizophrenia
• Spectrum - Massive analysis refines map of autism’s genetic roots

Grants

• For current PsychENCODE rollout, we are supported by several NIMH grants